Melatonin is a naturally occurring hormone produced in the brain by the pineal gland. Circulating levels of melatonin in the body vary throughout the day depending on environmental factors. The release and synthesis of melatonin are suppressed by light and stimulated by darkness; this suggests melatonin plays an integral role in circadian rhythms (biochemical, physiological or behavioral processes based on a 24 hour cycle) throughout the body.

Melatonin has been described as a pervasive and powerful antioxidant due to its ability to easily cross cell membranes and the blood-brain barrier. Certain trials have demonstrated melatonin's ability to prevent damage to DNA by some carcinogens as well as protect against immune disorders, cardiovascular disease, and depression. As research continues to uncover melatonin's many health giving benefits, it is most widely known for its sleep promoting properties. Since melatonin production is inhibited by light and permitted by darkness, as evening approaches the pineal gland secretes melatonin which causes drowsiness and lowers body temperature. Melatonin levels continue to increase and peak in the middle of the night but gradually taper by morning - this effect is known as the melatonin phase-response curve (PRC).

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