This herb has been shown to reduce blood sugar levels when used for an extended period of time. Gymnema also reduces the taste of sugar when it is placed in the mouth, so it is sometimes used to fight sugar cravings. Extracts from the leaves contain glycosides known as Gymnemic acids, which exhibit anti-sweet activity. This effect lasts up to about 2 hours. This effect was observed in rats in a 2003 study.

Gymnema is currently being used in some all natural medications for diabetes with other ingredients such as bitter melon and cinnamon.

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